Cart
sales@molnova.com
Home - Products - JAK/STAT Signaling - STAT - MNK8?

MNK8?

CAS No. 2055078-49-2

MNK8?( 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione )

Catalog No. M28976 CAS No. 2055078-49-2

3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 32 In Stock
5MG 33 In Stock
10MG 53 In Stock
25MG 98 In Stock
50MG 132 In Stock
100MG 198 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MNK8?
  • Note
    Research use only, not for human use.
  • Brief Description
    3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .
  • Description
    3-methyl-6- (naphthalen-1-yl)pyrimidine-2,4(1H, 3H)-dione is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells .(In Vitro):MNK8 (50 μM, 0-48 h) increased Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1 .
  • In Vitro
    MNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1.
  • In Vivo
    ——
  • Synonyms
    3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2055078-49-2
  • Formula Weight
    252.27
  • Molecular Formula
    C15H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (165.18 mM)
  • SMILES
    CN(C(C=C(c1cccc2ccccc12)N1)=O)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Estévez-Lao TY, Hillyer JF. Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses. Insect Biochem Mol Biol. 2014 Jan;44:12-22.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Asunaprevir

    Asunaprevir is an effective hepatitis C virus (HCV) NS3 protease inhibitor.

  • 2-NP

    2-NP increased the duration of STAT1 tyrosine phosphorylation in response to IFN-gamma, and this may underlie its enhancement of STAT1-dependent transcription.

  • Galiellalactone

    A small molecule, direct STAT3 inhibitor that inhibits the IL-6-induced SEAP expression with IC50 of 200-500 nM.

Sign In Join Free