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C188-9 (b)
CAS No. 425373-68-8
C188-9 (b)( C 188-9 )
Catalog No. M14443 CAS No. 425373-68-8
A novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameC188-9 (b)
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NoteResearch use only, not for human use.
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Brief DescriptionA novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand.
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DescriptionA novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand, suppresses cytokine-stimulated pSTAT3, reduces constitutive pSTAT3 activity, and inhibits anchorage dependent and independent growth of in multiple HNSCC cell lines; prevents tumor xenograft growth, modulates many STAT3-regulated genes involved in oncogenesis and radioresistance in vivo.Solid Tumors Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsC 188-9
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number425373-68-8
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Formula Weight469.555
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Molecular FormulaC28H23NO4S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-ethylbenzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Redell MS, et al. Blood. 2011 May 26;117(21):5701-9.
2. Bharadwaj U, et al. Oncotarget. 2016 May 3;7(18):26307-30.
3. Jung KH, et al. Clin Cancer Res. 2017 Sep 15;23(18):5537-5546.
4. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9.
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