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HQ461
CAS No. 1226443-41-9
HQ461( —— )
Catalog No. M28932 CAS No. 1226443-41-9
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | In Stock |
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| 2MG | 51 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 337 | In Stock |
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| 50MG | 555 | In Stock |
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| 100MG | 792 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1609 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHQ461
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NoteResearch use only, not for human use.
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Brief DescriptionHQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
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DescriptionHQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
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In VitroWestern Blot Analysis Cell Line:A549 cells Concentration:10 μM Incubation Time:0-8h Result:Induces 50% reduction of CDK12 protein level at 8 h, and>8 fold reduction of the CCNK protein level at 4 h.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1226443-41-9
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Formula Weight345.44
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Molecular FormulaC15H15N5OS2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (180.93 mM)
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SMILESCc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92.
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