Home - Products - Angiogenesis - CDK - HQ461

HQ461

CAS No. 1226443-41-9

HQ461( —— )

Catalog No. M28932 CAS No. 1226443-41-9

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	92	In Stock
2MG	51	In Stock
5MG	85	In Stock
10MG	147	In Stock
25MG	337	In Stock
50MG	555	In Stock
100MG	792	In Stock
200MG	Get Quote	In Stock
500MG	1609	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

HQ461
Note

Research use only, not for human use.
Brief Description

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
Description

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
In Vitro

Western Blot Analysis Cell Line:A549 cells Concentration:10 μM Incubation Time:0-8h Result:Induces 50% reduction of CDK12 protein level at 8 h, and>8 fold reduction of the CCNK protein level at 4 h.
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

1226443-41-9
Formula Weight

345.44
Molecular Formula

C15H15N5OS2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (180.93 mM)
SMILES

Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

BAY-958

BAY-958 (BAY958, LDC526)?is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1.
CK7

CK7, a?Cdk2/9?inhibitor, can be used for the synthesis of Nek1 inhibitor BSc5231 and BSc5367.
Purvalanol A

A potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.

Sign In Join Free