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HPK1-IN-7
CAS No. 2320462-65-3
HPK1-IN-7( —— )
Catalog No. M28709 CAS No. 2320462-65-3
HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 170 | In Stock |
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| 5MG | 264 | In Stock |
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| 10MG | 435 | In Stock |
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| 25MG | 710 | In Stock |
|
| 50MG | 972 | In Stock |
|
| 100MG | 1341 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHPK1-IN-7
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NoteResearch use only, not for human use.
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Brief DescriptionHPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
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DescriptionHPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
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In Vitro——
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In VivoAnimal Model:Mice (MC38 syngeneic tumor model)Dosage:100 mg/kg Administration:Oral; twice daily for 28 days Result:Enhanced the efficacy of anti-PD1 treatment, garnering a 100% cure rate vs a 20% cure rate with anti-PD1 alone.
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorEndothelin-1 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2320462-65-3
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Formula Weight458.478
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Molecular FormulaC24H22N6O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (272.65 mM)
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SMILESCC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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UR13870
UR-13870 (Org 48762-0) is an orally active and selective inhibitor of p38 mitogen-activated protein kinase (MAPK), which prevents bone damage in collagen-induced arthritis in mice.
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Bisabolangelone
Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities.?
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Darizmetinib
Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.
