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Thalidomide-NH-CH2-COOH

CAS No. 927670-97-1

Thalidomide-NH-CH2-COOH( (2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine | 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid )

Catalog No. M28260 CAS No. 927670-97-1

Thalidomide-NH-CH2-COOH is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 28 In Stock
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Biological Information

  • Product Name
    Thalidomide-NH-CH2-COOH
  • Note
    Research use only, not for human use.
  • Brief Description
    Thalidomide-NH-CH2-COOH is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.
  • Description
    Thalidomide-NH-CH2-COOH is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    (2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine | 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α7 nAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    927670-97-1
  • Formula Weight
    331.28
  • Molecular Formula
    C15H13N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (150.93 mM)
  • SMILES
    OC(CNc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lagostena L, et al. The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology. 2008 Mar;54(4):676-85.
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