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TH5427
CAS No. 2253744-56-6
TH5427( —— )
Catalog No. M28237 CAS No. 2253744-56-6
TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 227 | Get Quote |
|
| 5MG | 349 | Get Quote |
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| 10MG | 519 | Get Quote |
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| 25MG | 833 | Get Quote |
|
| 50MG | 1134 | Get Quote |
|
| 100MG | 1512 | Get Quote |
|
| 500MG | 3042 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTH5427
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NoteResearch use only, not for human use.
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Brief DescriptionTH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).
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DescriptionTH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).(In Vitro):In HL-60 cell lysates, TH5427(20 μM) stabilized NUDT5 to nearly the same levels as observed in the 37 °C DMSO control. TH5427 was the most potent stabilizer under the described conditions with an apparent EC50 of 2.1 μM. Accordingly, TH5427 had a positive, dose-dependent shift in the apparent Tagg—the temperature at which 50 % of the target protein denatures and aggregates (TH5427 shifted NUDT5 Tagg up to ≈ 8 °C).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2253744-56-6
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Formula Weight491.33
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Molecular FormulaC20H20Cl2N8O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (10.18 mM)
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SMILESCN(c1c(C(N2C)=O)n(Cc3nnc(-c(cc4)cc(Cl)c4Cl)o3)c(N3CCNCC3)n1)C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Villalva M, et al. Anti-Inflammatory and Antioxidant Activities from the Basolateral Fraction of Caco-2 Cells Exposed to a Rosmarinic Acid Enriched Extract. J Agric Food Chem. 2018 Feb 7;66(5):1167-1174.
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