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CDK12-IN-2
CAS No. 2244987-03-7
CDK12-IN-2( CDK12 inhibitor 2 )
Catalog No. M28236 CAS No. 2244987-03-7
CDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 255 | In Stock |
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| 5MG | 217 | In Stock |
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| 10MG | 376 | In Stock |
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| 25MG | 620 | In Stock |
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| 50MG | 870 | In Stock |
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| 100MG | 1172 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCDK12-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionCDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
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DescriptionCDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.(In Vitro):In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h.
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In Vitro——
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In Vivo——
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SynonymsCDK12 inhibitor 2
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PathwayAngiogenesis
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TargetCDK
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RecptorNF-κB|p38|Antifection|Trypanosoma cruzi|Leishmania tropica
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Research Area——
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Indication——
Chemical Information
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CAS Number2244987-03-7
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Formula Weight532.64
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Molecular FormulaC32H32N6O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (93.87 mM)
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SMILESN(C(NCC1=CC=CC=C1)=O)(C2=CC=C(C=C2)C3=CN(C)C(=O)C=C3)[C@H]4CC[C@H](NC5=CC=C(C#N)C=N5)CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.da Rosa R, et al. Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis. Eur J Med Chem. 2017 Mar 10;128:25-35.
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