Cart
sales@molnova.com
Afimetoran
CAS No. 2171019-55-7
Afimetoran( BMS-986256 )
Catalog No. M28229 CAS No. 2171019-55-7
Afimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
|
| 5MG | 187 | In Stock |
|
| 10MG | 312 | In Stock |
|
| 25MG | 530 | In Stock |
|
| 50MG | 733 | In Stock |
|
| 100MG | 1042 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAfimetoran
-
NoteResearch use only, not for human use.
-
Brief DescriptionAfimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases.
-
DescriptionAfimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases.
-
In Vitro——
-
In Vivo——
-
SynonymsBMS-986256
-
PathwayImmunology/Inflammation
-
TargetTLR
-
Recptormitotic kinesin Kif18A
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2171019-55-7
-
Formula Weight444.57
-
Molecular FormulaC26H32N6O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (224.94 mM)
-
SMILESCC(C)c1c(-c2cn3ncnc3c(C)c2C)[nH]c2c1cc(C1CCN(CC(N)=O)CC1)cc2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.
molnova catalog
related products
-
TLR7/8/9-IN-1
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
-
Resatorvid
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 nM).Resatorvid suppresses the production of NO, TNF-α, and IL-6 from LPS-stimulated human peripheral blood mononuclear cells (PBMCs, IC50s: 11-33 nM).
-
MMG-11
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7?μM for Pam3CSK4-induced hTLR2/1 and 5.7?μM for Pam2CSK4-induced hTLR2/6 responses.
