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CAY10786
CAS No. 1239987-91-7
CAY10786( GPR52 antagonist-1 )
Catalog No. M28063 CAS No. 1239987-91-7
CAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 2MG | 30 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 76 | In Stock |
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| 25MG | 168 | In Stock |
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| 50MG | 262 | In Stock |
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| 100MG | 421 | In Stock |
|
| 200MG | 609 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCAY10786
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NoteResearch use only, not for human use.
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Brief DescriptionCAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
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DescriptionCAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).(In Vitro):CAY10786 reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111cells in a concentration-dependent manner. CAY10786 (3 μM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons. (In Vivo):In the homozygous HdhQ140 mouse model of Huntington’s disease, CAY10786 (5 mg/kg) increases the latency to fall in the rotarod test and decreases striatal levels of soluble and insoluble mHTT.
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In Vitro——
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In VivoGPR52 antagonist-1 (Compound 43) (5 mg/kg; i.p.; once a day for 4 weeks) reduces mHTT levels and rescues HD-related phenotypes in HdhQ140 mice.
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SynonymsGPR52 antagonist-1
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PathwayCell Cycle/DNA Damage
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TargetGPR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1239987-91-7
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Formula Weight242.34
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Molecular FormulaC15H14OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (1031.61 mM)
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SMILESC(/C=C/CCC1=CC=CC=C1)(=O)C2=CC=CS2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Thangapandian S, et al. Molecular docking and pharmacophore filtering in the discovery of dual-inhibitors for human leukotriene A4 hydrolase and leukotriene C4 synthase. J Chem Inf Model. 2011 Jan 24;51(1):33-44.
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