Cart
sales@molnova.com
CAY10786
CAS No. 1239987-91-7
CAY10786( GPR52 antagonist-1 )
Catalog No. M28063 CAS No. 1239987-91-7
CAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
|
| 5MG | 50 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 177 | In Stock |
|
| 50MG | 282 | In Stock |
|
| 100MG | 444 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCAY10786
-
NoteResearch use only, not for human use.
-
Brief DescriptionCAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
-
DescriptionCAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).(In Vitro):CAY10786 reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111cells in a concentration-dependent manner. CAY10786 (3 μM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons. (In Vivo):In the homozygous HdhQ140 mouse model of Huntington’s disease, CAY10786 (5 mg/kg) increases the latency to fall in the rotarod test and decreases striatal levels of soluble and insoluble mHTT.
-
In Vitro——
-
In VivoGPR52 antagonist-1 (Compound 43) (5 mg/kg; i.p.; once a day for 4 weeks) reduces mHTT levels and rescues HD-related phenotypes in HdhQ140 mice.
-
SynonymsGPR52 antagonist-1
-
PathwayCell Cycle/DNA Damage
-
TargetGPR
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1239987-91-7
-
Formula Weight242.34
-
Molecular FormulaC15H14OS
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 250 mg/mL (1031.61 mM)
-
SMILESC(/C=C/CCC1=CC=CC=C1)(=O)C2=CC=CS2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Thangapandian S, et al. Molecular docking and pharmacophore filtering in the discovery of dual-inhibitors for human leukotriene A4 hydrolase and leukotriene C4 synthase. J Chem Inf Model. 2011 Jan 24;51(1):33-44.
molnova catalog
related products
-
AS 1269574
AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.
-
cangrelor tetrasodiu...
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.cangrelor, a non-sepesific GPR17 antagonist, alleviates pulmonary fibrosis partly by inhibiting macrophage inflammation in mice.
-
CID 2745687
CID 2745687 is a GPR35 antagonist that inhibited the effects at human GPR35 of cromolyn disodium and zaprinast, two agonists that share an overlapping binding site.
