P2Y2R/GPR17 antagonist 1( —— )

Catalog No. M35640 CAS No. 2395016-49-4

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual antagonist with an IC50 of 3.17 μM for P2Y2R and 1.67 μM for GPR17.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

P2Y2R/GPR17 antagonist 1
Note

Research use only, not for human use.
Brief Description

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual antagonist with an IC50 of 3.17 μM for P2Y2R and 1.67 μM for GPR17.
Description

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 μM and 1.67 μM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

GPR
Recptor

GPR
Research Area

——
Indication

——

Chemical Information

CAS Number

2395016-49-4
Formula Weight

432.83
Molecular Formula

C19H13ClN2O6S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (288.80 mM; Ultrasonic )
SMILES

[O-][N+](=O)c1cccc(OS(=O)(=O)c2ccc(NC(=O)c3ccccc3Cl)cc2)c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.?

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