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5-Hydroxy-1-methylhydantoin
CAS No. 84210-26-4
5-Hydroxy-1-methylhydantoin( NZ-419 | HD-003 )
Catalog No. M27907 CAS No. 84210-26-4
NZ-419 is an antioxidant potentially for the treatment of renal failure.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 44 | In Stock |
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| 25MG | 89 | In Stock |
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| 50MG | 138 | In Stock |
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| 100MG | 207 | In Stock |
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| 200MG | 305 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name5-Hydroxy-1-methylhydantoin
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NoteResearch use only, not for human use.
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Brief DescriptionNZ-419 is an antioxidant potentially for the treatment of renal failure.
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DescriptionNZ-419 is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, NZ-419, a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. NZ-419 a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. NZ-419 inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that NZ-419 may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
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In Vitro——
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In Vivo——
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SynonymsNZ-419 | HD-003
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PathwayGPCR/G Protein
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TargetBradykinin Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number84210-26-4
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Formula Weight114.1
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Molecular FormulaC4H6N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC(CN1C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dana M, et al. Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials. Molecules. 2011 May 5;16(5):3826-44.
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