Icatibant Acetate( —— )

Catalog No. M23545 CAS No. 138614-30-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Icatibant Acetate
Note

Research use only, not for human use.
Brief Description

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.
Description

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.
In Vitro

——
In Vivo

Animal Model:Female mice of the CBA/J (H-2k) strain.Dosage:0.06, 0.3, or 1.5 mg/kg.Administration:Subcutaneous administration twice daily.Result:The length of the large intestine was 93.6±6.8 mm with the 1.5 mg/kg dosage and 94.0±4.1 mm with the 0.3 mg/kg dosage , showing a significant preventive effect on shortening.
Synonyms

——
Pathway

GPCR/G Protein
Target

Bradykinin Receptor
Recptor

bradykinin B2
Research Area

——
Indication

——

CAS Number

138614-30-9
Formula Weight

1364.57
Molecular Formula

C61H93N19O15S
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL?(73.28 mM;?Need ultrasonic)
SMILES

CC(=O)O.N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3cccs3)C(=O)N[C@@H](CO)C(=O)N4Cc5ccccc5C[C@@H]4C(=O)N6[C@H]7CCCC[C@H]7C[C@H]6C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical Name

——

1.Charignon D, et al. Expert Opin Pharmacother. 2012, 13(15):2233-47.

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