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Triparanol

CAS No. 78-41-1

Triparanol( NSC 65345 | NSC-65345 | NSC65345 )

Catalog No. M27836 CAS No. 78-41-1

Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 690 In Stock
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10MG 866 In Stock
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Biological Information

  • Product Name
    Triparanol
  • Note
    Research use only, not for human use.
  • Brief Description
    Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling.
  • Description
    Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.(In Vitro):Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol.
  • In Vitro
    Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol.
  • In Vivo
    ——
  • Synonyms
    NSC 65345 | NSC-65345 | NSC65345
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    A2A/A1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    78-41-1
  • Formula Weight
    438.01
  • Molecular Formula
    C27H32ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (114.16 mM)
  • SMILES
    CCN(CC)CCOc1ccc(cc1)C(O)(Cc1ccc(Cl)cc1)c1ccc(C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9.
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