IMM-01

Research use only, not for human use.

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division.

IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics.

Apoptosis Analysis Cell Line:NIH 3T3 cells and SW480 cells Concentration:1 μM, 10 μM, or 100 μM Incubation Time:48 hours Result:Induced caspase-3 cleavage.

Animal Model:Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells Dosage:5 mg/kg, 25 mg/kg Administration:i.v.; 2 times a week; for 3 weeks Result:Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.

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Others

Other Targets

CYP3A4|Calcium Channel|P-gp

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218795-74-5

267.35

C12H17N3O2S

>98% (HPLC)

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CC(C)(C)NC(=S)N\N=C\c1ccc(O)cc1O

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(-20℃)

With Ice Pack

≥ 2 years