5J-4

Research use only, not for human use.

5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.

5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.(In Vivo):5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation.

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5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE. Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)Dosage:2 m/kg Administration:I.p., every alternate day for 30 days Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.

5J 4 | 5J4

GPCR/G Protein

Calcium Channel

CDK4|CDK6

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827001-82-1

312.34

C16H12N2O3S

>98% (HPLC)

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Oc1ccc2c(NC(=S)NC(=O)c3ccco3)cccc2c1

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(-20℃)

With Ice Pack

≥ 2 years