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Home - Products - GPCR/G Protein - Calcium Channel - 5J-4

5J-4

CAS No. 827001-82-1

5J-4( 5J 4 | 5J4 )

Catalog No. M27803 CAS No. 827001-82-1

5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 105 In Stock
5MG 93 In Stock
10MG 146 In Stock
25MG 250 In Stock
50MG 367 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    5J-4
  • Note
    Research use only, not for human use.
  • Brief Description
    5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.
  • Description
    5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.(In Vivo):5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation.
  • In Vitro
    ——
  • In Vivo
    5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE. Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)Dosage:2 m/kg Administration:I.p., every alternate day for 30 days Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.
  • Synonyms
    5J 4 | 5J4
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    CDK4|CDK6
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    827001-82-1
  • Formula Weight
    312.34
  • Molecular Formula
    C16H12N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Oc1ccc2c(NC(=S)NC(=O)c3ccco3)cccc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Richard Paul Beckmann, et al. Combination therapy with notch and cdk4/6 inhibitors for the treatment of cancer. WO2017180389A1.
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