Sal003( SAL-003 | SAL 003 | SAL003 )

Catalog No. M17162 CAS No. 1164470-53-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Sal003
Note

Research use only, not for human use.
Brief Description

Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
Description

SAL-003 is a cell-permeable inhibitor of eIF2α dephosphorylation. SAL003 is an Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Sal003 mediated upregulation of eIF2α phosphorylation suppressed cisplatin induced p53 activation. Furthermore, reduction of eIF2α phosphorylation by PERK knockdown enhanced cisplatin-induced p53 activation and apoptosis.
In Vitro

Apoptosis Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:1 hour Result:Phosphorylated eIF2α and thus enhanced SubAB-induced apoptotic signaling.Western Blot Analysis Cell Line:Mouse embryonic fibroblasts (MEFs)Concentration:20 μM Incubation Time:1 hour, 3 hours, 6 hours, 12 hours Result:Sharply increased eIF2α phosphorylation in mouse MEFs.
In Vivo

Animal Model:Rats (300-325g)Dosage:20 μM Administration:Intrahippocampal injection; 8 minutes Result:Impaired contextual memory.
Synonyms

SAL-003 | SAL 003 | SAL003
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

eIF-2α phosphatase
Research Area

Cancer
Indication

——

CAS Number

1164470-53-4
Formula Weight

463.21
Molecular Formula

C18H15Cl4N3OS
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 215.88 mM
SMILES

c1ccc(cc1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc1ccc(cc1)Cl
Chemical Name

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

1. Robert F, et al. Mol Biol Cell. 2006, 17(11), 4632-4644.

Calculator

molnova catalog