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Roslin 2 bromide
CAS No. 29574-21-8
Roslin 2 bromide( Benzylhexamethylenetetramine bromide )
Catalog No. M27793 CAS No. 29574-21-8
Roslin 2 bromide is a p53 reactivator that disrupts the binding of FAK and p5Roslin 2 bromide exhibits anticancer effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 2MG | 35 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 143 | In Stock |
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| 50MG | 209 | In Stock |
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| 100MG | 308 | In Stock |
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| 200MG | 443 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRoslin 2 bromide
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NoteResearch use only, not for human use.
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Brief DescriptionRoslin 2 bromide is a p53 reactivator that disrupts the binding of FAK and p5Roslin 2 bromide exhibits anticancer effects.
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DescriptionRoslin 2 bromide is a p53 reactivator that disrupts the binding of FAK and p5Roslin 2 bromide exhibits anticancer effects.(In Vitro):Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner.(In Vivo):Roslin 2 bromide (60 mg/kg; i.p) significantly decreased tumor growth, disrupts the complex of FAK and p53, and up-regulated p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts.
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In VitroRoslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins.
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In VivoRoslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo.
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SynonymsBenzylhexamethylenetetramine bromide
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PathwayAngiogenesis
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TargetFAK
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RecptorHuman Endogenous Metabolite|Drug Metabolite|Parasite|Purine nucleoside phosphorylase
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Research Area——
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Indication——
Chemical Information
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CAS Number29574-21-8
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Formula Weight311.227
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Molecular FormulaC13H19BrN4
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Purity>98% (HPLC)
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Solubility——
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SMILES[Br-].C(c1ccccc1)[N+]12CN3CN(CN(C3)C1)C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.
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