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Home - Products - Metabolic Enzyme/Protease - Phosphatase - PTP1B-IN-4

PTP1B-IN-4

CAS No. 765317-72-4

PTP1B-IN-4( FRJ | NUN17724 | NUN-17724 | NUN 17724 | PTP1B inhibitor 4 | PTP1B-inhibitor-4 | )

Catalog No. M27767 CAS No. 765317-72-4

PTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PTP1B-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    PTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
  • Description
    PTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.(In Vitro):In CHO cells overexpressing human IR, PTP1B-IN-4 (250 μM) stimulates the phosphorylation of insulin receptors. PTP1B-IN-4 induces phosphorylation of IRS-1 and Akt which are proteins downstream of the insulin receptor.
  • In Vitro
    Western Blot Analysis Cell Line:CHO cells Concentration:250 μM Incubation Time:1 hour Result:Stimulated insulin receptor phosphorylation.
  • In Vivo
    ——
  • Synonyms
    FRJ | NUN17724 | NUN-17724 | NUN 17724 | PTP1B inhibitor 4 | PTP1B-inhibitor-4 |
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    FAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    765317-72-4
  • Formula Weight
    741.45
  • Molecular Formula
    C26H19Br2N3O7S3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (134.87 mM)
  • SMILES
    CCc1oc2cc(ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1)S(O)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yang XH, Xiang L, Li X, Zhao TT, Zhang H, Zhou WP, Wang XM, Gong HB, Zhu HL. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorg Med Chem. 2012 May 1;20(9):2789-95.
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