Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - Qc1

Qc1

CAS No. 403718-45-6

Qc1( Qc 1 )

Catalog No. M27692 CAS No. 403718-45-6

Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 53 Get Quote
5MG 87 Get Quote
10MG 155 Get Quote
25MG 259 Get Quote
50MG 390 Get Quote
100MG 565 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Qc1
  • Note
    Research use only, not for human use.
  • Brief Description
    Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.
  • Description
    Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.(In Vitro):Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine and blocks the charging of tetrahydrofolate(THF). In ES cells, Qc1 (10 μM) increases autophagic activity.
  • In Vitro
    Qc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity.. Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine.
  • In Vivo
    ——
  • Synonyms
    Qc 1
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    PAR-1|Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    403718-45-6
  • Formula Weight
    455.45
  • Molecular Formula
    C23H16F3N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (137.23 mM)
  • SMILES
    FC(F)(F)c1cccc(c1)N1C(=S)N=C2C=C(C=C[C@@H]2C1=O)C(=O)NCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Di Serio C, et al. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Basic Clin Pharmacol Toxicol. 2007 Jul;101(1):63-9.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GSK864

    GSK864 is an IDH1 mutant inhibitor that inhibits IDH1 mutants R132C, R132H, and R132G, and is used in the study of cardiovascular and oncology diseases.

  • CAY10566

    CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.

  • AZD1981

    AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors.

Sign In Join Free