m-Chlorophenylbiguanide hydrochloride

Research use only, not for human use.

m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist.

m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 μM) over 5-HT1A(Ki: 10 μM) and 5-HT2(Ki: 10 μM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 μM, respectively, in rat caudate putamen synaptosomal membranes).(In Vivo):m-Chlorophenylbiguanide hydrochloride induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 μM, respectively).m-Chlorophenylbiguanide hydrochloride induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).

——

Animal Model:Wistar male ratsDosage:80, 160 and 320 nM Administration:Ventricle injection Result:Decreased water intake induced by water deprivation, acute salt load and hypovolemia.

1-(3-Chlorophenyl)biguanidehydrochloride

Endocrinology/Hormones

5-HT Receptor

——

——

——

2113-05-5

248.11

C8H11Cl2N5

>98% (HPLC)

In Vitro:?H2O : 125 mg/mL (503.81 mM)

Cl.NC(=N)NC(=N)Nc1cccc(Cl)c1

——

(-20℃)

With Ice Pack

≥ 2 years