cis-Urocanic acid

Research use only, not for human use.

cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.

cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.(In Vitro):Treatment with 100 μg/mL cis-Urocanic acid completely suppresses IL-6 and IL-8 secretion decreases caspase-3 activity and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types .

Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic Cell Viability Assay Cell Line:Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs)Concentration:10, 100, 1,000, and 5,000 μg/mL Incubation Time:24, 48, or 72 hours Result:Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types.

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(Z)-Urocanic acid | cis-UCA | (E)-Urocanic acid | (Z)-Imidazole-4-acrylic acid | (Z)-3-(1H-Imidazol-5-yl)acrylic acid

Endocrinology/Hormones

5-HT Receptor

Alkyl-Chain

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7699-35-6

138.126

C6H6N2O2

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (362.00 mM)

OC(=O)\C=C/c1cnc[nH]1

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(-20℃)

With Ice Pack

≥ 2 years