Buspirone

Research use only, not for human use.

Buspirone free base is an agonist of serotonin receptor with anxiolytic activity. Buspirone free base has an efficacy comparable to diazepam.

Buspirone free base is an agonist of serotonin receptor with anxiolytic activity. Buspirone free base has an efficacy comparable to diazepam.

Buspirone (0-400 μg/mL; 6 hours) has cytotoxic effect in Lymphocytes.Buspirone (0-180 μg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG). Cell Viability Assay Cell Line:Lymphocytes Concentration:0, 4, 20, 40, 200 and 400 μg/mL Incubation Time:6 hours Result:Decreased cell viability in a dose-dependent manner.

Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors.Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota. Animal Model:Male C57BL/6N mice Dosage:1 and 5 mg/kg Administration:Oral gavage and intraperitoneal injection; for 5 days Result:Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.Animal Model:Male C57BL/6N mice Dosage:1 and 5 mg/kg Administration:Oral gavage and intraperitoneal injection; for 5 days Result:Reduced the IS- or EC-induced gut Proteobacteria population.

Buspirone free base | Ansial

Endocrinology/Hormones

5-HT Receptor

EGFR (T790M)|EGFR (L858R/T790M)|EGFR (del19/T790M)

——

——

36505-84-7

385.512

C21H31N5O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (259.40 mM)

O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1

——

(-20℃)

With Ice Pack

≥ 2 years