Ondansetron hydrochloride( Ondansetron hydrochloride )

Catalog No. M10182 CAS No. 103639-04-9

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Product Name

Ondansetron hydrochloride
Note

Research use only, not for human use.
Brief Description

Ondansetron is a serotonin 5-HT receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
Description

Ondansetron is a serotonin 5-HT receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.(In Vivo):Ondansetron hydrochloride dehydrate (2 mg/kg; i.p.; single) blocks radiation sickness when combines with Dexamethasone (2 mg/kg) and CP-99,994 (15 mg/kg), in radiation-induced pica model.
In Vitro

——
In Vivo

Ondansetron hydrochloride dehydrate (2 mg/kg; i.p.; single) blocks radiation sickness when combines with Dexamethasone (2 mg/kg) and CP-99,994 (15 mg/kg), in radiation-induced pica model. Animal Model:Male mice of ICR strain (8-week-old; 30-36 g; radiation-induced pica model (kaolin ingestion behavior “pica” may be analogous to nausea and vomiting in mice)).Dosage:2 mg/kg Administration:Intraperitoneal injection; single.Result:Slightly reduced the radiation-induced kaolin consumption by dexamethasone to 48% of the control.Showed good activity of blocking radiation sickness by combining with Dexamethasone (2 mg/kg) and CP-99,994 (15 mg/kg).
Synonyms

Ondansetron hydrochloride
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT3
Research Area

Neurological Disease
Indication

——

CAS Number

103639-04-9
Formula Weight

365.86
Molecular Formula

C18H19N3O·HCl·2H2O
Purity

>98% (HPLC)
Solubility

Soluble in DMSO
SMILES

O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl
Chemical Name

1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride

1.Arcioni R, et al. Anesth Analg. 2002 Jun;94(6):1553-7.

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