2-BFI hydrochloride

Research use only, not for human use.

2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.

2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease.(In Vivo):2-BFI hydrochloride administration after dMCAO improved the neurological deficits and decreased the infarct volume. 2-BFI hydrochloride reduced phosphorylation of mTOR and p70S6, increased IL-10 and TGF-β, and decreased IFN-γ levels in ischemic rats. 2-BFI hydrochloride attenuates ischemic injury by inhibiting the activation of mTOR signaling and modulating neuroinflammation after stroke in rats.

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Animal Model:280-300 g, Male adult Sprague-Dawley rats (TBI model)Dosage:5, 10, 20 mg/kg Administration:I.p.; twice daily for 3 days Result:Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.

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Others

Other Targets

BRM/BRG1

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89196-95-2

222.67

C11H11ClN2O

>98% (HPLC)

In Vitro:?DMSO : 20.83 mg/mL (93.55 mM)

Cl.N1=C(NCC1)C=2OC=3C=CC=CC3C2

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(-20℃)

With Ice Pack

≥ 2 years