Chronic intracerebroventricular (ICV) injection of a VGF peptide named TLQP-21 increased resting energy expenditure and temperature in mice. Furthermore, in mice fed a high-fat diet, the same peptide prevented the increase in body and white adipose tissue (WAT) weight as well as hormonal changes associated with a high-fat regimen.

Osthol hydrate is a natural product.

2-Phenylethylamine hydrochloride acts as neuromodulator in the central nervous system.?It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes.