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Alloxazine
CAS No. 490-59-5
Alloxazine( —— )
Catalog No. M27527 CAS No. 490-59-5
Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 100MG | 28 | In Stock |
|
| 200MG | 38 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAlloxazine
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NoteResearch use only, not for human use.
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Brief DescriptionAlloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
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DescriptionAlloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
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In VitroAlloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells. Cell Viability Assay Cell Line:PGT-β cells Concentration:0-30 μM Incubation Time:20 min Result:Inhibited the cyclic AMP generation concentration-dependently with an IC50 of 2.9 μM.
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In VivoAlloxazine (1 μmol/L; cortical surface suffusion for 0-20 min) suppresses NECA-induced vasodilation. Animal Model:Male Sprague-Dawley rats Dosage:1 μmol/L Administration:Cortical surface suffusion; 1 μmol/L once Result:Significantly suppressed vasodilation with increased EC25 value of 0.60 μmol/L.
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Synonyms——
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PathwayApoptosis
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TargetAdenosine Receptor
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Recptorglucokinase
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Research Area——
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Indication——
Chemical Information
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CAS Number490-59-5
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Formula Weight214.184
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Molecular FormulaC10H6N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (23.34 mM)
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SMILESO=c1[nH]c2nc3ccccc3nc2c(=O)[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dzyurkevich MS, et al. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. Sci Rep. 2017 Nov 22;7(1):16072.
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