NS3694

Research use only, not for human use.

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.

NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.(In Vitro):NS3694 (10, 50, and 100 μM) specifically inhibits cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. In MCF-casp3 cells, NS3694 (10-100 μM) inhibits dose-dependently caspase 9, 3, and 7 processing, DFF45/ICAD, and PARP cleavage, and DEVDase activity and inhibits TNF-induced effector caspase activation and apoptosis.

When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed.NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells.NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9. Western Blot Analysis Cell Line:HeLa cells Concentration:10 μM, 50 μM, 100 μM Incubation Time:120 min Result:Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.

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Apoptosis

Apoptosis

non-cleavable ADC linker|Alkyl-Chain

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426834-38-0

358.7

C15H10ClF3N2O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (696.96 mM)

O=C(O)C1=CC=C(Cl)C=C1NC(=O)NC2=CC=CC(=C2)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years