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Cl-amidine hydrochloride

CAS No. 1373232-26-8

Cl-amidine hydrochloride( —— )

Catalog No. M23526 CAS No. 1373232-26-8

Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cl-amidine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4).
  • Description
    Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
  • In Vitro
    Apoptosis Analysis.Cell Line:TK6 lymphoblastoid cells and HT29 colon cancer cells. Concentration:0, 5, 10, 15, 20, 25, 50 μg/mL.Incubation Time:24 h.Result:Induced apoptosis dose-dependently.
  • In Vivo
    Animal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis).Dosage:75 mg/kg.Administration:IP once daily.Result:Suppressed PAD activity, protein citrullination, and PAD levels in the colon in vivo.Animal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis). Dosage:5, 25, 75 mg/kg.Administration:Oral gavage once daily.Result:Led to significant reductions in the histology scores.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|MicroRNA|PAD4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1373232-26-8
  • Formula Weight
    347.24
  • Molecular Formula
    C14H20Cl2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:50 mg/mL (143.99 mM; Need ultrasonic);DMSO:19.23 mg/mL (55.38 mM; Need ultrasonic)
  • SMILES
    O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yuan Luo, et al. Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization. Biochemistry. 2006 Oct 3; 45(39): 11727–11736.
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