GBR 12783 dihydrochloride

Research use only, not for human use.

GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.

GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.(In Vivo):GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.

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GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task. Animal Model:Male Sprague-Dawley rats (180-200 g) Dosage:10 mg/kg Administration:Intraperitoneal injection; for 100 minutes Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.

GBR12783 2HCl

Others

Other Targets

AMPAR

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67469-75-4

485.49

C28H34Cl2N2O

>98% (HPLC)

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Cl.Cl.C(CN1CCN(C\C=C\c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years