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(S,R,S)-AHPC TFA

CAS No. 1631137-51-3

(S,R,S)-AHPC TFA( VH032-NH2 TFA | VHL ligand 1 TFA )

Catalog No. M26954 CAS No. 1631137-51-3

(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (S,R,S)-AHPC TFA
  • Note
    Research use only, not for human use.
  • Brief Description
    (S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
  • Description
    (S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VH032-NH2 TFA | VHL ligand 1 TFA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hERG| σ1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1631137-51-3
  • Formula Weight
    544.59
  • Molecular Formula
    C24H31F3N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.
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