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(S,R,S)-AHPC-PEG4-N3
CAS No. 1797406-81-5
(S,R,S)-AHPC-PEG4-N3( VH032-PEG4-N3 | VHL Ligand-Linker Conjugates 5 | E3 ligase Ligand-Linker Conjugates 4 )
Catalog No. M26950 CAS No. 1797406-81-5
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 5MG | 61 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 148 | In Stock |
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| 50MG | 237 | In Stock |
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| 100MG | 423 | In Stock |
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Biological Information
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Product Name(S,R,S)-AHPC-PEG4-N3
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NoteResearch use only, not for human use.
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Brief Description(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
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Description(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.(In Vitro):E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins.
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In VitroE3?ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins.
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In Vivo——
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SynonymsVH032-PEG4-N3 | VHL Ligand-Linker Conjugates 5 | E3 ligase Ligand-Linker Conjugates 4
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PathwayOthers
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TargetOther Targets
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RecptorATP-sensitive potassium (KATP) channels
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Research Area——
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Indication——
Chemical Information
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CAS Number1797406-81-5
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Formula Weight689.82
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Molecular FormulaC32H47N7O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 100 mg/mL (144.97 mM)
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SMILESO=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN=[N+]=[N-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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ML-180
ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling.
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Shield-1
Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein.
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6-chloro-1-ethyl-7-(...
6-chloro-1-ethyl-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a compound used as a molecular building block.
