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Tradipitant
CAS No. 622370-35-8
Tradipitant( VLY-686 | LY686017 )
Catalog No. M26851 CAS No. 622370-35-8
Tradipitant is an antagonist of neurokinin-1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 151 | In Stock |
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| 2MG | 73 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 330 | In Stock |
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| 50MG | 480 | In Stock |
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| 100MG | 684 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTradipitant
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NoteResearch use only, not for human use.
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Brief DescriptionTradipitant is an antagonist of neurokinin-1.
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DescriptionTradipitant is an antagonist of neurokinin-1.(In Vitro):Tradipitant binds to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral), and the medial amygdaloid nucleus .(In Vivo):Tradipitant (intravenously administered) treatment localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands .
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In VitroResults reveal that Tradipitant ([3H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal).
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In VivoAutoradiography experiments reveal that intravenously administered Tradipitant ([3H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands.
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SynonymsVLY-686 | LY686017
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorNucleoside Antimetabolite/Analog
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Research Area——
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Indication——
Chemical Information
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CAS Number622370-35-8
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Formula Weight587.91
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Molecular FormulaC28H16ClF6N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (170.10 mM)
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SMILESFC(F)(F)c1cc(Cn2nnc(c2-c2ccncc2)-c2ncccc2C(=O)c2ccccc2Cl)cc(c1)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Raynal NJ, et al. 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase. Leuk Res. 2011 Jan;35(1):110-8.
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