Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Neurokinin Receptor - SB 218795

SB 218795

CAS No. 174635-53-1

SB 218795( —— )

Catalog No. M27703 CAS No. 174635-53-1

SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 111 In Stock
2MG 58 In Stock
5MG 92 In Stock
10MG 163 In Stock
25MG 330 In Stock
50MG 523 In Stock
100MG 737 In Stock
200MG Get Quote In Stock
500MG 1553 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SB 218795
  • Note
    Research use only, not for human use.
  • Brief Description
    SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
  • Description
    SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.(In Vitro):SB 218795 (3-30 nM) antagonizes the contractile responses senktide-induced in a surmountable and concentration-dependent manner.(In Vivo):In rabbits, SB 218795 (0.25-1 mg/kg; i.v.) inhibits NK3 receptor-mediated pupillary constriction by maximum inhibition of 78%.
  • In Vitro
    SB 218795 (3-30 nM) antagonizes the contractile responses induced by the NK3 receptor agonist senktide in a surmountable and concentration-dependent manner.SB 218795 (0.3-3?μM) does not affect the contractile responses of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter muscle.
  • In Vivo
    SB?218795 (0.25-1?mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Neurokinin Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    174635-53-1
  • Formula Weight
    396.446
  • Molecular Formula
    C25H20N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (630.61 mM)
  • SMILES
    COC(=O)[C@@H](NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Carnat A1, et al. Luteolin 7-diglucuronide, the major flavonoid compound from Aloysia triphylla and Verbena officinalis.Planta Med. 1995 Oct;61(5):490.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • [Sar9,Met(O2)11]-Sub...

    Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.

  • [Nle11]-Substance P

    [Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.

  • Befetupitant

    Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.

Sign In Join Free