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Tolrestat
CAS No. 82964-04-3
Tolrestat( AY-27773 )
Catalog No. M26849 CAS No. 82964-04-3
Tolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 88 | In Stock |
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| 10MG | 148 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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Biological Information
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Product NameTolrestat
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NoteResearch use only, not for human use.
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Brief DescriptionTolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).
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DescriptionTolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).(In Vivo):The estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively in diabetic rats. Tolrestat inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice. Tolrestat (1.8 mg/kg) causes a reversal of normal RBC sorbitol levels.
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In Vitro——
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In VivoTolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice.
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SynonymsAY-27773
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PathwayEndocrinology/Hormones
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TargetReductase
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RecptorSIRT7
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Research Area——
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Indication——
Chemical Information
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CAS Number82964-04-3
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Formula Weight357.35
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Molecular FormulaC16H14F3NO3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (139.92 mM)
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SMILESCOc1ccc2c(cccc2c1C(F)(F)F)C(=S)N(C)CC(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.
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