Sulcotrione

Research use only, not for human use.

Sulcotrione is a β-triketone herbicide. It also can inhibit hydroxyphenylpyruvate dioxygenase.

Sulcotrione is a β-triketone herbicide. It also can inhibit hydroxyphenylpyruvate dioxygenase.(In Vitro):Sulcotrione behaves as time-independent reversible inhibitor. However it is the first time that such behavior is observed using a purified hydroxyphenylpyruvate dioxygenase and a synthetic β-triketone, namely sulcotrione. Inhibition kinetic analysis, performing with 3 hydroxyphenylpyruvate and sulcotrione concentrations, show that the apparent KM increasing with sulcotrione concentration .

The results show that sulcotrione behaves as time-independent reversible inhibitor. Similar results are previously described for natural β-triketones, and for the synthetic β-triketone NTBC. However it is the first time that such behavior is observed using a purified hydroxyphenylpyruvate dioxygenase (HPPD) and a synthetic β-triketone, namely sulcotrione. Inhibition kinetic analysis, performing with 3 hydroxyphenylpyruvate (HPP)and sulcotrione concentrations, show that the apparent KM increasing with sulcotrione concentration. This behavior is consistent with the data present in the literature, describing sulcotrione as a competitive inhibitor of HPPD.

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Immunology/Inflammation

ROS

Cathepsin L

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99105-77-8

328.76

C14H13ClO5S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (304.16 mM)

CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years