Methotrexate metabolite

Research use only, not for human use.

Methotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.

Methotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth.(In Vitro):Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR).

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DAMPA

Cell Cycle/DNA Damage

Antifolate

Antibiotic| Bacterial

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19741-14-1

325.332

C15H15N7O2

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (15.37 mM)

CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years