LRE1( —— )

Catalog No. M26744 CAS No. 1252362-53-0

LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	33	In Stock
25MG	65	In Stock
50MG	119	In Stock
100MG	177	In Stock
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Biological Information

Product Name

LRE1
Note

Research use only, not for human use.
Brief Description

LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.
Description

LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor.(In Vitro):LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition. LRE1 binds to the bicarbonate activator binding site and suppresses soluble adenylyl cyclase (sAC) via a unique allosteric mechanism.
In Vitro

Western Blot Analysis Cell Line:Mouse cauda sperm Concentration:0.5-100 μM Incubation Time:60 minutes Result:LRE1 inhibits sAC dependent sperm capacitation.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

S1PR1
Research Area

——
Indication

——

Chemical Information

CAS Number

1252362-53-0
Formula Weight

280.77
Molecular Formula

C12H13ClN4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (445.19 mM)
SMILES

Nc1nc(Cl)cc(n1)N(Cc1cccs1)C1CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Bigaud M, et al. Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. PLoS One. 2016 Dec 22;11(12):e0168252.

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