L-NMMA acetate

Research use only, not for human use.

L-NMMA acetate is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3).

L-NMMA acetate is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 μM for nNOS, eNOS, and iNOS, respectively.(In Vitro):L-NMMA acetate inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. L-NMMA acetate does not affect isoprenaline-induced relaxation . The inhibitory effect of L-NMMA acetate is unchanged by previous incubation with D-arginine while it is prevented by L-arginine. L-NMMA acetate, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The Superfusion of L-NMMA acetate decreases arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA acetate is nearly immediate. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA acetate .

L-NMMA, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The inhibitory effect of L-NMMA is unchanged by previous incubation with D-arginine while it is prevented by L-arginine (L-Arg). L-NMMA does not affect isoprenaline-induced relaxation. Superfusion of L-NMMA reduces arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA is nearly immediate. L-NMMA inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA.

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Tilarginine acetate | Methylarginine acetate

Immunology/Inflammation

NOS

Bax| Caspase-3| IAP

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53308-83-1

248.283

C9H20N4O4

>98% (HPLC)

In Vitro:?H2O : ≥ 50 mg/mL (201.39 mM)*)

CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years