JW 642( —— )

Catalog No. M26726 CAS No. 1416133-89-5

JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL)

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	32	In Stock
10MG	31	In Stock
25MG	62	In Stock
50MG	110	In Stock
100MG	206	In Stock
200MG	306	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

JW 642
Note

Research use only, not for human use.
Brief Description

JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL)
Description

JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).(In Vitro):MAGL inhibitor JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s: 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Lipase
Recptor

HPPD
Research Area

——
Indication

——

Chemical Information

CAS Number

1416133-89-5
Formula Weight

462.392
Molecular Formula

C21H20F6N2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 100 mg/mL (216.27 mM)
SMILES

FC(F)(F)C(OC(=O)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Rocaboy-Faquet E, et al. A novel amperometric biosensor for ?-triketone herbicides based on hydroxyphenylpyruvatedioxygenase inhibition: A case study for sulcotrione. Talanta. 2016;146:510-6.

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