Indobufen

Research use only, not for human use.

Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes.

Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes.(In Vitro):Indobufen suppresses TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen causes the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered. Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels.

Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels. Indobufen inhibits TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen reduces the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered.

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Ibustrin

Chromatin/Epigenetic

COX

RSV

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63610-08-2

295.338

C18H17NO3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (846.51 mM)

CCC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O

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(-20℃)

With Ice Pack

≥ 2 years