Chebulagic acid( —— )

Catalog No. M22791 CAS No. 23094-71-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Chebulagic acid
Note

Research use only, not for human use.
Brief Description

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Chebulagic acid can enhance autophagy and exerts anti-inflammatory and anti-infective effects.
Description

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Chebulagic acid can enhance autophagy and exerts anti-inflammatory and anti-infective effects. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner.
In Vitro

Chebulagic acid can enhance the autophagy. Chebulagic acid exert anti-inflammatory and anti-infective effects. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+)-induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. Furthermore, LPS-activated MAPK signaling is inhibited by Chebulagic acid treatment in the EA.hy926 cells.
In Vivo

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Synonyms

——
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX| LOX
Research Area

——
Indication

——

CAS Number

23094-71-5
Formula Weight

954.66
Molecular Formula

C41H27O27
Purity

>98% (HPLC)
Solubility

DMSO:98 mg/mL (102.66 mM; Need ultrasonic)
SMILES

OC(CC(C(O[C@H]([C@@H](COC(C1=CC(O)=C2O)=O)O[C@@H]3OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@H](OC(C5=CC(O)=C(O)C(O)=C5C1=C2O)=O)[C@H]3OC6=O)=O)C(C7O)C(C6=CC(O)=C8O)=C8OC7=O)=O
Chemical Name

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1. Kim HJ et al. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol Ther (Seoul). 2014 Jul;22(4):275-81.

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