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Gardiquimod
CAS No. 1020412-43-4
Gardiquimod( —— )
Catalog No. M26693 CAS No. 1020412-43-4
Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 140 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGardiquimod
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NoteResearch use only, not for human use.
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Brief DescriptionGardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells.
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DescriptionGardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells. Gardiquimod is an imidazoquinoline analog and is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7.(In Vitro):Administration of 6-60 μM Gardiquimod obviously inhibits HIV-1 reverse transcriptase cDNA synthesis.(In Vivo):Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) in combination with Dendritic cells (DCs) enhance the anti-tumor effects of NK cells.
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In VitroGardiquimod (6-60?μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase.
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In VivoDendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells. Animal Model:Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts)Dosage:1 mg/kg per mouse Administration:i.p.; daily for 7 days Result:Significantly suppressed the growth of human HepG2 liver carcinoma xenografts.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorEstrogen Receptor/ERR| Human Endogenous Metabolite
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Research Area——
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Indication——
Chemical Information
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CAS Number1020412-43-4
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Formula Weight313.405
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Molecular FormulaC17H23N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMF : ≥ 20 mg/mL (63.82 mM)DM)
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SMILESCCNCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hernández N, et al. 4-Hydroxyestradiol improves mouse embryo quality, epidermal growth factor-binding capability in vitro and implantation rates. Mol Hum Reprod. 2021 Feb 5;27(2):gaaa075.
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