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Fenobam
CAS No. 57653-26-6
Fenobam( —— )
Catalog No. M26686 CAS No. 57653-26-6
Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 98 | In Stock |
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| 25MG | 164 | In Stock |
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| 50MG | 242 | In Stock |
|
| 100MG | 351 | In Stock |
|
| 200MG | 486 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFenobam
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NoteResearch use only, not for human use.
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Brief DescriptionFenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity.
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DescriptionFenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).(In Vivo):Fenobam sulfate (30-60 mg/kg; p.o.) inhibited cocaine self-administration significantly .
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In Vitro——
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In VivoAnimal Model:Male Long-Evans rats (250-300 g)Dosage:30-60 mg/kg Administration:P.o.Result:Inhibited self-administration
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorMAGL
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Research Area——
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Indication——
Chemical Information
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CAS Number57653-26-6
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Formula Weight266.69
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Molecular FormulaC11H11ClN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (374.98 mM)
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SMILESCN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shuhei Ikeda, et al. Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H-benzo[ b][1,4]oxazin-6-yl Moiety. J Med Chem. 2021 Aug 12;64(15):11014-11044.
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