Ercalcidiol

Research use only, not for human use.

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.(In Vitro):The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and Ercalcidiol binds less well to the vitamin D binding protein, making Ercalcidiol less potent and required much higher doses than vitamin D3 .

Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2.

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25-hydroxy Vitamin D2

Proteasome/Ubiquitin

Endogenous Metabolite

RUVBL1/2

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21343-40-8

412.658

C28H44O2

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (484.67 mM)

[H][C@@]12CC[C@H]([C@H](C)\C=C\[C@H](C)C(C)(C)O)[C@@]1(C)CCC\C2=C/C=C1/C[C@@H](O)CCC1=C

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(-20℃)

With Ice Pack

≥ 2 years