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Auristatin F
CAS No. 163768-50-1
Auristatin F( —— )
Catalog No. M26616 CAS No. 163768-50-1
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 52 | In Stock |
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| 10MG | 71 | In Stock |
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| 25MG | 110 | In Stock |
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| 50MG | 156 | In Stock |
|
| 100MG | 228 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAuristatin F
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NoteResearch use only, not for human use.
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Brief DescriptionAuristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.
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DescriptionAuristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.(In Vitro):Auristatin F and Monomethyl Auristatin F (MMAF) are potent cytotoxins used in ADCs.
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In VitroAuristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates.
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In VivoAuristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has Cmax of 8276.76 ng/mL. The AUClast is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat.
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number163768-50-1
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Formula Weight746.003
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Molecular FormulaC40H67N5O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (268.10 mM)
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SMILES[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vázquez-Victorio G, et al. Fabrication of Adhesive Substrate for Incorporating Hydrogels to Investigate the Influence of Stiffness on Cancer Cell Behavior. Methods Mol Biol. 2021;2174:277-297.
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