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VU6005649
CAS No. 2137047-43-7
VU6005649( —— )
Catalog No. M26504 CAS No. 2137047-43-7
VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 35 | In Stock |
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| 25MG | 71 | In Stock |
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| 50MG | 113 | In Stock |
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| 100MG | 178 | In Stock |
|
| 200MG | 253 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU6005649
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NoteResearch use only, not for human use.
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Brief DescriptionVU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
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DescriptionVU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).(In Vitro):VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50.(In Vivo):In wild-type mice, VU6005649 shows modest but significant pro-cognitive effects on associative learning and the first example of the efficacy of a mGlu7/8 positive allosteric modulator (PAM) in this model.
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In VitroVU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively. VU6005649 displays a terminal Kp of 2.43 with total brain levels ~9× above the mGlu7 positive allosteric modulator (PAM) in vitro EC50.
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In VivoWhen VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H2O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model.
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2137047-43-7
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Formula Weight357.284
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Molecular FormulaC16H12F5N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (139.95 mM)
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SMILESCOc1ccc(-c2c(C)nn3c(cc(C)nc23)C(F)(F)F)c(F)c1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen XL, et al. An uncommon plant growth regulator, diethyl aminoethyl hexanoate, is highly effective in tissue cultures of the important medicinal plant purple coneflower (Echinacea purpurea L.). Biomed Res Int. 2013;2013:540316.
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