Valecobulin hydrochloride( CKD-516 hydrochloride )

Catalog No. M26496 CAS No. 1240321-53-2

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Product Name

Valecobulin hydrochloride
Note

Research use only, not for human use.
Brief Description

Valecobulin hydrochloride is a potent inhibitor of β-tubulin polymerization.
Description

Valecobulin hydrochloride is a potent inhibitor of β-tubulin polymerization. Valecobulin hydrochloride is a valine prodrug and a vascular disrupting agent.(In Vivo):In male BALB/C nu/nu mice, Valecobulin hydrochloride (5 mg/kg; i.p) showed markedly antitumor efficacy in various human tumor xenograft models.
In Vitro

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In Vivo

Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models. Animal Model:Male BALB/C nu/nu mice (5-6 weeks of age) with HCT-116 or HCT-15 cells Dosage:5 mg/kg Administration:Intraperitoneal injection; administered on days 2, 6, 10, and 14 Result:Had shown marked antitumor efficacy in various human tumor xenograft models.
Synonyms

CKD-516 hydrochloride
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

——
Research Area

——
Indication

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CAS Number

1240321-53-2
Formula Weight

573.07
Molecular Formula

C26H29ClN6O5S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (218.13 mM)
SMILES

Cl.COc1cc(cc(OC)c1OC)C(=O)c1ccc(cc1-n1cncn1)-c1csc(NC(=O)[C@@H](N)C(C)C)n1
Chemical Name

——

1.Meyer BN, McLaughlin JL, Keller WJ. Candicine from Stapelia gigantea. Planta Med. 1981 Nov;43(11):304-6.

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