Mevociclib( SY-1365 )

Catalog No. M26471 CAS No. 1816989-16-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Mevociclib
Note

Research use only, not for human use.
Brief Description

Mevociclib is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
Description

Mevociclib is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
In Vitro

——
In Vivo

Animal Model:Mice, HCC70 xenograft model Dosage:20 mg/kg Administration:Intravenous injection, twice weekly, for 35 days Result:Inhibited tumor volume in vivo.
Synonyms

SY-1365
Pathway

Angiogenesis
Target

CDK
Recptor

Akt| caspase-3| JNK1| p44/42 MAPK| RhoGDI
Research Area

——
Indication

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CAS Number

1816989-16-8
Formula Weight

587.13
Molecular Formula

C31H35ClN8O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (212.90 mM)
SMILES

CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@@]1(C)CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
Chemical Name

——

1.Kohno K, Ohashi E, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015 Jan 20;12(1):2.

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