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Kenpaullone

CAS No. 142273-20-9

Kenpaullone( 9-Bromopaullone | NSC-664704 )

Catalog No. M11777 CAS No. 142273-20-9

Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 65 In Stock
2MG 43 In Stock
5MG 61 In Stock
10MG 91 In Stock
25MG 188 In Stock
50MG 312 In Stock
100MG 463 In Stock
200MG Get Quote In Stock
500MG 1051 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Kenpaullone
  • Note
    Research use only, not for human use.
  • Brief Description
    Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM).
  • Description
    Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM); shows less effect on other kinases, only c-Src, CK2, ERK1/2 (IC50=15-20 uM) with IC50s less than 30 uM; displays delayed cell cycle progression in treated cells; also is a potent inhibitor of GSK-3β (IC50=23 nM), activates Nanog expression in mouse fibroblasts transduced with a subset of reprogramming factors lacking Klf4, can replace Klf4 in the reprogramming of primary and secondary fibroblasts and NPCs.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    9-Bromopaullone | NSC-664704
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK1/CyclinB|CDK2/CyclinA|CDK2/CyclinE|CDK5/p35|GSK-3β
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    142273-20-9
  • Formula Weight
    327.1754
  • Molecular Formula
    C16H11BrN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    O=C(NC1=CC=CC=C12)CC3=C2NC4=C3C=C(Br)C=C4
  • Chemical Name
    Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zaharevitz DW, et al. Cancer Res. 1999 Jun 1;59(11):2566-9. 2. Schultz C, et al. J Med Chem. 1999 Jul 29;42(15):2909-19. 3. Bain J, et al. Biochem J. 2003 Apr 1;371(Pt 1):199-204. 4. Lyssiotis CA, et al. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7.
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