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PNU-112455A

CAS No. 21886-12-4

PNU-112455A( PNU112455A )

Catalog No. M13491 CAS No. 21886-12-4

PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	72	In Stock
2MG	37	In Stock
5MG	65	In Stock
10MG	102	In Stock
25MG	182	In Stock
50MG	275	In Stock
100MG	449	In Stock
200MG	Get Quote	In Stock
500MG	995	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

PNU-112455A
Note

Research use only, not for human use.
Brief Description

PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively.
Description

PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-c-Met, IGR-1R, and ERK2.
In Vitro

——
In Vivo

——
Synonyms

PNU112455A
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

Chemical Information

CAS Number

21886-12-4
Formula Weight

301.749
Molecular Formula

C10H12ClN5O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (414.25 mM)
SMILES

O=S(C1=CC=C(NC2=NC=NC(N)=C2)C=C1)(N)=O.[H]Cl
Chemical Name

N4-(6-aminopyrimidin-4-yl)-sulfanilamide hydrochloride

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Clare PM, et al. J Biol Chem. 2001 Dec 21;276(51):48292-9. 2. Monaco EA 3rd, et al. Biochem Pharmacol. 2004 May 15;67(10):1947-64.

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