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PNU-112455A
CAS No. 21886-12-4
PNU-112455A( PNU112455A )
Catalog No. M13491 CAS No. 21886-12-4
PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 38 | Get Quote |
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| 5MG | 61 | Get Quote |
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| 10MG | 113 | Get Quote |
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| 25MG | 221 | Get Quote |
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| 50MG | 342 | Get Quote |
|
| 100MG | 513 | Get Quote |
|
| 500MG | 1125 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePNU-112455A
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NoteResearch use only, not for human use.
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Brief DescriptionPNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively.
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DescriptionPNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-c-Met, IGR-1R, and ERK2.
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In Vitro——
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In Vivo——
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SynonymsPNU112455A
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number21886-12-4
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Formula Weight301.749
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Molecular FormulaC10H12ClN5O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (414.25 mM)
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SMILESO=S(C1=CC=C(NC2=NC=NC(N)=C2)C=C1)(N)=O.[H]Cl
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Chemical NameN4-(6-aminopyrimidin-4-yl)-sulfanilamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Clare PM, et al. J Biol Chem. 2001 Dec 21;276(51):48292-9.
2. Monaco EA 3rd, et al. Biochem Pharmacol. 2004 May 15;67(10):1947-64.
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